Lara Fuhrmann
I am Lara Fuhrmann and I come from Germany. I obtained my Bachelor’s and Master’s degrees in Mathematics at the University of Bonn, Germany. During my Master’s studies, I learned about the field of computational biology and got very much interested in the application of computational methods in the setting of biology. In the scope of my master thesis, I created a mathematical model to describe the dynamics of communicating cell populations based on single-cell RNA data.
During this period, I got intrigued by using mathematical knowledge and tools to improve the understanding of biological processes. Following this idea, I joined ETH Zurich in Switzerland in November 2020 to work in the field of computational virology.
I am very excited to be part of this interdisciplinary research network, and I am looking forward to broadening my knowledge on viruses and the interactions with their hosts, and to contribute to a better understanding of the processes involved.
I am always up for outdoor activities, in particular running, hiking, and tennis. In winter, I love to go snowboarding in the Swiss Alps.
Field:
Bioinformatics
Host institution:
Swiss Federal Institute of Technology Zurich (ETH), Switzerland
Local supervisor:
Prof. Dr. Niko Beerenwinkel (ETH Zurich)
Local co-supervisor:
Prof. Dr. Karin Metzner (University Hospital Zurich)
Project partners:
Harshit Prajapati (ESR 4)
Oscar Morales Lezcano (ESR 9)
Work packages:
WP 1.3 Virus-host interactions
WP 2.1 Microevolution: Virus quasispecies
Project description
Viruses exist in their hosts as populations of genetically heterogeneous particles often referred to as viral quasispecies. Intra- host genomic diversity can result in phenotypic heterogeneity, and it has been linked to viral pathogenesis and virulence. NGS can be used to assess the genomic heterogeneity of virus populations in a cost-efficient manner, but this approach is challenging due to sequencing errors and short read length. In this work package, we will develop improved tools for the reconstruction of viral genomic diversity from both short-read (Illumina) and long-read (PacBio, MinION) NGS data, and we will leverage the power of the inferred population structure to inform models of virus micro-evolution, to detect selection, and to correlate population features to viral and host phenotypes.
Specifically, the objectives are:
- Reconstruction of viral haplotypes (full-length strain) from NGS data (BC) while removing sequencing errors, including application to Drosophila C virus (ESR 9) and Deformed wing virus (ESR 4) quasispecies data.
- Extension by fitting parametric representations of virus populations (e.g. mutation-selection balance).
- Detection of patterns of positive or negative selection after viral passaging.
- Investigation of the correlation between viral quasispecies and (viral and host) phenotypes such as viral load, host immune response and survival, and specific readouts of virus-induced pathology.
Journal Articles
Fuhrmann, Lara; Jablonski, Kim Philipp; Topolsky, Ivan; Batavia, Aashil A; Borgsmüller, Nico; Baykal, Pelin Icer; Carrara, Matteo; Chen, Chaoran; Dondi, Arthur; Dragan, Monica; Dreifuss, David; John, Anika; Langer, Benjamin; Okoniewski, Michal; du Plessis, Louis; Schmitt, Uwe; Singer, Franziska; Stadler, Tanja; Beerenwinkel, Niko
V-pipe 3.0: a sustainable pipeline for within-sample viral genetic diversity estimation Journal Article
In: GigaScience, vol. 13, pp. giae065, 2024.
@article{Fuhrmann2024b,
title = {V-pipe 3.0: a sustainable pipeline for within-sample viral genetic diversity estimation},
author = {Lara Fuhrmann and Kim Philipp Jablonski and Ivan Topolsky and Aashil A Batavia and Nico Borgsmüller and Pelin Icer Baykal and Matteo Carrara and Chaoran Chen and Arthur Dondi and Monica Dragan and David Dreifuss and Anika John and Benjamin Langer and Michal Okoniewski and Louis du Plessis and Uwe Schmitt and Franziska Singer and Tanja Stadler and Niko Beerenwinkel},
doi = {10.1093/gigascience/giae065},
year = {2024},
date = {2024-09-30},
urldate = {2024-09-30},
journal = {GigaScience},
volume = {13},
pages = {giae065},
abstract = {The large amount and diversity of viral genomic datasets generated by next-generation sequencing technologies poses a set of challenges for computational data analysis workflows, including rigorous quality control, scaling to large sample sizes, and tailored steps for specific applications. Here, we present V-pipe 3.0, a computational pipeline designed for analyzing next-generation sequencing data of short viral genomes. It is developed to enable reproducible, scalable, adaptable, and transparent inference of genetic diversity of viral samples. By presenting 2 large-scale data analysis projects, we demonstrate the effectiveness of V-pipe 3.0 in supporting sustainable viral genomic data science.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Fuhrmann, Lara; Langer, Benjamin; Topolsky, Ivan; Beerenwinkel, Niko
VILOCA: Sequencing quality-aware haplotype reconstruction and mutation calling for short- and long-read data Journal Article
In: bioRxiv, 2024.
@article{Fuhrmann2024,
title = {VILOCA: Sequencing quality-aware haplotype reconstruction and mutation calling for short- and long-read data},
author = {Lara Fuhrmann and Benjamin Langer and Ivan Topolsky and Niko Beerenwinkel},
doi = {10.1101/2024.06.06.597712},
year = {2024},
date = {2024-06-09},
journal = {bioRxiv},
abstract = {RNA viruses exist in large heterogeneous populations within their host. The structure and diversity of virus populations affects disease progression and treatment outcomes. Next-generation sequencing allows detailed viral population analysis, but inferring diversity from error-prone reads is challenging. Here, we present VILOCA, a method for mutation calling and reconstruction of local haplotypes from short- and long-read viral sequencing data. Local haplotypes refer to genomic regions that have approximately the length of the input reads. VILOCA recovers local haplotypes by using a Dirichlet process mixture model to cluster reads around their unobserved haplotypes and leveraging quality scores of the sequencing reads. We assessed the performance of VILOCA in terms of mutation calling and haplotype reconstruction accuracy on simulated and experimental Illumina, PacBio, and Oxford Nanopore data. On simulated and experimental Illumina data, VILOCA performed better or similar to existing methods. On the simulated long-read data, VILOCA is able to recover on average 82% of the ground truth mutations with perfect precision compared to only 64% recall and 90% precision of the second-best method. In summary, VILOCA provides significantly improved accuracy in mutation and haplotype calling, especially for long-read sequencing data, and therefore facilitates the comprehensive characterization of heterogeneous within-host viral populations.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Lezcano, Oscar M.; Fuhrmann, Lara; Ramakrishnan, Gayatri; Beerenwinkel, Niko; Huynen, Martijn A.; van Rij, Ronald P.
Parallel evolution and enhanced virulence upon in vivo passage of an RNA virus in Drosophila melanogaster. Journal Article
In: Virus Evol, vol. 9, iss. 2, pp. vead074, 2023.
@article{Lezcano2023,
title = {Parallel evolution and enhanced virulence upon in vivo passage of an RNA virus in \textit{Drosophila melanogaster}.},
author = {Oscar M. Lezcano and Lara Fuhrmann and Gayatri Ramakrishnan and Niko Beerenwinkel and Martijn A. Huynen and Ronald P. van Rij },
doi = {10.1093/ve/vead074},
year = {2023},
date = {2023-12-15},
urldate = {2023-12-15},
journal = {Virus Evol},
volume = {9},
issue = {2},
pages = {vead074},
abstract = {Virus evolution is strongly affected by antagonistic co-evolution of virus and host. Host immunity positively selects for viruses that evade the immune response, which in turn may drive counter-adaptations in host immune genes. We investigated how host immune pressure shapes virus populations, using the fruit fly Drosophila melanogaster and its natural pathogen Drosophila C virus (DCV), as a model. We performed an experimental evolution study in which DCV was serially passaged for ten generations in three fly genotypes differing in their antiviral RNAi response: wild-type flies and flies in which the endonuclease gene Dicer-2 was either overexpressed or inactivated. All evolved virus populations replicated more efficiently in vivo and were more virulent than the parental stock. The number of polymorphisms increased in all three host genotypes with passage number, which was most pronounced in Dicer-2 knockout flies. Mutational analysis showed strong parallel evolution, as mutations accumulated in a specific region of the VP3 capsid protein in every lineage in a host genotype-independent manner. The parental tyrosine at position ninety-five of VP3 was substituted with either one of five different amino acids in fourteen out of fifteen lineages. However, no consistent amino acid changes were observed in the viral RNAi suppressor gene 1A, nor elsewhere in the genome in any of the host backgrounds. Our study indicates that the RNAi response restricts the sequence space that can be explored by viral populations. Moreover, our study illustrates how evolution towards higher virulence can be a highly reproducible, yet unpredictable process.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Graf, Christiana; Fuhrmann, Lara; Lutz, Thomas; Stephan, Christoph; Knecht, Gaby; Gute, Peter; Bickel, Markus; Peiffer, Kai-Henrik; Finkelmeier, Fabian; Dultz, Georg; Mondorf, Antonia; Wetzstein, Nils; Filmann, Natalie; Herrmann, Eva; Zeuzem, Stefan; Beerenwinkel, Niko; Dietz, Julia; Sarrazin, Christoph
Expanding epidemic of recently acquired HCV in HIV-coinfected patients over a period of 10 years Journal Article
In: JHEP Rep, vol. 5, iss. 7, pp. 100701, 2023.
@article{nokey,
title = {Expanding epidemic of recently acquired HCV in HIV-coinfected patients over a period of 10 years},
author = {Christiana Graf and Lara Fuhrmann and Thomas Lutz and Christoph Stephan and Gaby Knecht and Peter Gute and Markus Bickel and Kai-Henrik Peiffer and Fabian Finkelmeier and Georg Dultz and Antonia Mondorf and Nils Wetzstein and Natalie Filmann and Eva Herrmann and Stefan Zeuzem and Niko Beerenwinkel and Julia Dietz and Christoph Sarrazin},
doi = {10.1016/j.jhepr.2023.100701},
year = {2023},
date = {2023-02-19},
journal = {JHEP Rep},
volume = {5},
issue = {7},
pages = {100701},
abstract = {Background & aims: Ongoing transmission of HCV infections is associated with risk factors such as drug injection, needlestick injuries, and men who have sex with men (MSM). Ways of transmission, the course of acute infection, changes of virologic features, and incidence over time are not well known.
Methods: Over a period of 10 years, n = 161 patients with recently acquired HCV infection (RAHC) (median follow-up 6.8 years) were prospectively enrolled. NS5B sequencing was performed to re-evaluate the HCV genotype (GT) and for phylogenetic analyses.
Results: Patients with RAHC were mainly male (92.5%), MSM (90.1%), and HIV-coinfected (86.3%). Transmission risk factors for MSM and non-MSM were sexual risk behaviour (100 and 6.3%, respectively), injection drug use (9.7 and 37.5%, respectively), and nasal drug use (15.2 and 0%, respectively). Spontaneous and interferon- or direct-acting antiviral-based clearance rates were 13.6, 84.3 and 93.4%, respectively. Mean RAHC declined from 19.8 in the first to 13.2 in the past five study years. Although the majority of infections was caused by HCV GT1a, the frequency of HCV GT4d and slightly HCV GT3a increased over time. No relevant clustering of HCV isolates was observed in non-MSM. However, 45% of HCV GT1a and 100% of HCV GT4d MSM cases clustered with MSM isolates from other countries. Travel-associated infections were supported by personal data in an MSM subgroup. No international clustering was detected in MSM with HCV GT1b or HCV GT3a.
Conclusions: RAHCs were mainly diagnosed in HIV-coinfected MSM patients and were associated with sexual risk behaviour. Spontaneous clearance rates were low, and phylogenetic clusters were observed in the majority of patients.
Impact and implications: We evaluated the occurrence and transmission of recently acquired HCV infections (RAHCs) over a period of 10 years. Our data demonstrate that the presence of RAHC was mainly found in HIV-coinfected MSM, with internationally connected transmission networks being observed in the majority of patients. Spontaneous clearance rates were low, and reinfection rates increased mainly driven by a small subset of MSM patients with high-risk behaviour.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Methods: Over a period of 10 years, n = 161 patients with recently acquired HCV infection (RAHC) (median follow-up 6.8 years) were prospectively enrolled. NS5B sequencing was performed to re-evaluate the HCV genotype (GT) and for phylogenetic analyses.
Results: Patients with RAHC were mainly male (92.5%), MSM (90.1%), and HIV-coinfected (86.3%). Transmission risk factors for MSM and non-MSM were sexual risk behaviour (100 and 6.3%, respectively), injection drug use (9.7 and 37.5%, respectively), and nasal drug use (15.2 and 0%, respectively). Spontaneous and interferon- or direct-acting antiviral-based clearance rates were 13.6, 84.3 and 93.4%, respectively. Mean RAHC declined from 19.8 in the first to 13.2 in the past five study years. Although the majority of infections was caused by HCV GT1a, the frequency of HCV GT4d and slightly HCV GT3a increased over time. No relevant clustering of HCV isolates was observed in non-MSM. However, 45% of HCV GT1a and 100% of HCV GT4d MSM cases clustered with MSM isolates from other countries. Travel-associated infections were supported by personal data in an MSM subgroup. No international clustering was detected in MSM with HCV GT1b or HCV GT3a.
Conclusions: RAHCs were mainly diagnosed in HIV-coinfected MSM patients and were associated with sexual risk behaviour. Spontaneous clearance rates were low, and phylogenetic clusters were observed in the majority of patients.
Impact and implications: We evaluated the occurrence and transmission of recently acquired HCV infections (RAHCs) over a period of 10 years. Our data demonstrate that the presence of RAHC was mainly found in HIV-coinfected MSM, with internationally connected transmission networks being observed in the majority of patients. Spontaneous clearance rates were low, and reinfection rates increased mainly driven by a small subset of MSM patients with high-risk behaviour.
Jahn, Katharina; Dreifuss, David; Topolsky, Ivan; Kull, Anina; Ganesanandamoorthy, Pravin; Fernandez-Cassi, Xavier; Bänziger, Carola; Devaux, Alexander J.; Stachler, Elyse; Caduff, Lea; Cariti, Federica; Corzón, Alex Tuñas; Fuhrmann, Lara; Chen, Chaoran; Jablonski, Kim Philipp; Nadeau, Sarah; Feldkamp, Mirjam; Beisel, Christian; Aquino, Catharine; Stadler, Tanja; Ort, Christoph; Kohn, Tamar; Julian, Timothy R.; Beerenwinkel, Niko
Early detection and surveillance of SARS-CoV-2 genomic variants in wastewater using COJAC Journal Article
In: Nat Microbiol, 2022.
@article{nokey,
title = {Early detection and surveillance of SARS-CoV-2 genomic variants in wastewater using COJAC},
author = {Katharina Jahn and David Dreifuss and Ivan Topolsky and Anina Kull and Pravin Ganesanandamoorthy and Xavier Fernandez-Cassi and Carola Bänziger and Alexander J. Devaux and Elyse Stachler and Lea Caduff and Federica Cariti and Alex Tuñas Corzón and Lara Fuhrmann and Chaoran Chen and Kim Philipp Jablonski and Sarah Nadeau and Mirjam Feldkamp and Christian Beisel and Catharine Aquino and Tanja Stadler and Christoph Ort and Tamar Kohn and Timothy R. Julian and Niko Beerenwinkel},
doi = {10.1038/s41564-022-01185-x},
year = {2022},
date = {2022-07-18},
urldate = {2022-07-18},
journal = {Nat Microbiol},
abstract = {The continuing emergence of SARS-CoV-2 variants of concern and variants of interest emphasizes the need for early detection and epidemiological surveillance of novel variants. We used genomic sequencing of 122 wastewater samples from three locations in Switzerland to monitor the local spread of B.1.1.7 (Alpha), B.1.351 (Beta) and P.1 (Gamma) variants of SARS-CoV-2 at a population level. We devised a bioinformatics method named COJAC (Co-Occurrence adJusted Analysis and Calling) that uses read pairs carrying multiple variant-specific signature mutations as a robust indicator of low-frequency variants. Application of COJAC revealed that a local outbreak of the Alpha variant in two Swiss cities was observable in wastewater up to 13 d before being first reported in clinical samples. We further confirmed the ability of COJAC to detect emerging variants early for the Delta variant by analysing an additional 1,339 wastewater samples. While sequencing data of single wastewater samples provide limited precision for the quantification of relative prevalence of a variant, we show that replicate and close-meshed longitudinal sequencing allow for robust estimation not only of the local prevalence but also of the transmission fitness advantage of any variant. We conclude that genomic sequencing and our computational analysis can provide population-level estimates of prevalence and fitness of emerging variants from wastewater samples earlier and on the basis of substantially fewer samples than from clinical samples. Our framework is being routinely used in large national projects in Switzerland and the UK.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Chen, Chaoran; Nadeau, Sarah Ann; Topolsky, Ivan; Manceau, Marc; Huisman, Jana S.; Jablonski, Kim Philipp; Fuhrmann, Lara; Dreifuss, David; Jahn, Katharina; Beckmann, Christiane; Redondo, Maurice; Noppen, Christoph; Risch, Lorenz; Risch, Martin; Wohlwend, Nadia; Kas, Sinem; Bodmer, Thomas; Roloff, Tim; Stange, Madlen; Egli, Adrian; Eckerle, Isabella; Kaiser, Laurent; Denes, Rebecca; Feldkamp, Mirjam; Nissen, Ina; Santacroce, Natascha; Burcklen, Elodie; Aquino, Catharine; de Gouvea, Andreia Cabral; Moccia, Maria Domenica; Grüter, Simon; Sykes, Timothy; Opitz, Lennart; White, Griffin; Neff, Laura; Popovic, Doris; Patrignani, Andrea; Tracy, Jay; Schlapbach, Ralph; Dermitzakis, Emmanouil T; Harshman, Keith; Xenarios, Ioannis; Pegeot, Henri; Cerutti, Lorenzo; Penet, Deborah; Blin, Anthony; Elies, Melyssa; Althaus, Christian L.; Beisel, Christian; Beerenwinkel, Niko; Ackermann, Martin; Stadler, Tanja
Quantification of the spread of SARS-CoV-2 variant B.1.1.7 in Switzerland Journal Article
In: Epidemics, vol. 37, pp. 100480, 2021.
@article{nokey,
title = {Quantification of the spread of SARS-CoV-2 variant B.1.1.7 in Switzerland},
author = {Chaoran Chen and Sarah Ann Nadeau and Ivan Topolsky and Marc Manceau and Jana S. Huisman and Kim Philipp Jablonski and Lara Fuhrmann and David Dreifuss and Katharina Jahn and Christiane Beckmann and Maurice Redondo and Christoph Noppen and Lorenz Risch and Martin Risch and Nadia Wohlwend and Sinem Kas and Thomas Bodmer and Tim Roloff and Madlen Stange and Adrian Egli and Isabella Eckerle and Laurent Kaiser and Rebecca Denes and Mirjam Feldkamp and Ina Nissen and Natascha Santacroce and Elodie Burcklen and Catharine Aquino and Andreia Cabral de Gouvea and Maria Domenica Moccia and Simon Grüter and Timothy Sykes and Lennart Opitz and Griffin White and Laura Neff and Doris Popovic and Andrea Patrignani and Jay Tracy and Ralph Schlapbach and Emmanouil T Dermitzakis and Keith Harshman and Ioannis Xenarios and Henri Pegeot and Lorenzo Cerutti and Deborah Penet and Anthony Blin and Melyssa Elies and Christian L. Althaus and Christian Beisel and Niko Beerenwinkel and Martin Ackermann and Tanja Stadler},
doi = {10.1016/j.epidem.2021.100480},
year = {2021},
date = {2021-08-09},
urldate = {2021-08-09},
journal = {Epidemics},
volume = {37},
pages = {100480},
abstract = {Background: In December 2020, the United Kingdom (UK) reported a SARS-CoV-2 Variant of Concern (VoC) which is now named B.1.1.7. Based on initial data from the UK and later data from other countries, this variant was estimated to have a transmission fitness advantage of around 40-80 % (Volz et al., 2021; Leung et al., 2021; Davies et al., 2021).
Aim: This study aims to estimate the transmission fitness advantage and the effective reproductive number of B.1.1.7 through time based on data from Switzerland.
Methods: We generated whole genome sequences from 11.8 % of all confirmed SARS-CoV-2 cases in Switzerland between 14 December 2020 and 11 March 2021. Based on these data, we determine the daily frequency of the B.1.1.7 variant and quantify the variant's transmission fitness advantage on a national and a regional scale.
Results: We estimate B.1.1.7 had a transmission fitness advantage of 43-52 % compared to the other variants circulating in Switzerland during the study period. Further, we estimate B.1.1.7 had a reproductive number above 1 from 01 January 2021 until the end of the study period, compared to below 1 for the other variants. Specifically, we estimate the reproductive number for B.1.1.7 was 1.24 [1.07-1.41] from 01 January until 17 January 2021 and 1.18 [1.06-1.30] from 18 January until 01 March 2021 based on the whole genome sequencing data. From 10 March to 16 March 2021, once B.1.1.7 was dominant, we estimate the reproductive number was 1.14 [1.00-1.26] based on all confirmed cases. For reference, Switzerland applied more non-pharmaceutical interventions to combat SARS-CoV-2 on 18 January 2021 and lifted some measures again on 01 March 2021.
Conclusion: The observed increase in B.1.1.7 frequency in Switzerland during the study period is as expected based on observations in the UK. In absolute numbers, B.1.1.7 increased exponentially with an estimated doubling time of around 2-3.5 weeks. To monitor the ongoing spread of B.1.1.7, our plots are available online.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Aim: This study aims to estimate the transmission fitness advantage and the effective reproductive number of B.1.1.7 through time based on data from Switzerland.
Methods: We generated whole genome sequences from 11.8 % of all confirmed SARS-CoV-2 cases in Switzerland between 14 December 2020 and 11 March 2021. Based on these data, we determine the daily frequency of the B.1.1.7 variant and quantify the variant's transmission fitness advantage on a national and a regional scale.
Results: We estimate B.1.1.7 had a transmission fitness advantage of 43-52 % compared to the other variants circulating in Switzerland during the study period. Further, we estimate B.1.1.7 had a reproductive number above 1 from 01 January 2021 until the end of the study period, compared to below 1 for the other variants. Specifically, we estimate the reproductive number for B.1.1.7 was 1.24 [1.07-1.41] from 01 January until 17 January 2021 and 1.18 [1.06-1.30] from 18 January until 01 March 2021 based on the whole genome sequencing data. From 10 March to 16 March 2021, once B.1.1.7 was dominant, we estimate the reproductive number was 1.14 [1.00-1.26] based on all confirmed cases. For reference, Switzerland applied more non-pharmaceutical interventions to combat SARS-CoV-2 on 18 January 2021 and lifted some measures again on 01 March 2021.
Conclusion: The observed increase in B.1.1.7 frequency in Switzerland during the study period is as expected based on observations in the UK. In absolute numbers, B.1.1.7 increased exponentially with an estimated doubling time of around 2-3.5 weeks. To monitor the ongoing spread of B.1.1.7, our plots are available online.
Fuhrmann, Lara; Jablonski, Kim Philipp; Beerenwinkel, Niko
Quantitative measures of within-host viral genetic diversity Journal Article
In: Curr Opin Virol, vol. 49, pp. 157-163, 2021.
@article{nokey,
title = {Quantitative measures of within-host viral genetic diversity},
author = {Lara Fuhrmann and Kim Philipp Jablonski and Niko Beerenwinkel
},
doi = {10.1016/j.coviro.2021.06.002},
year = {2021},
date = {2021-06-18},
urldate = {2021-06-18},
journal = {Curr Opin Virol},
volume = {49},
pages = {157-163},
abstract = {The genetic diversity of virus populations within their hosts is known to influence disease progression, treatment outcome, drug resistance, cell tropism, and transmission risk, and the study of dynamic changes of genetic heterogeneity can provide insights into the evolution of viruses. Several measures to quantify within-host genetic diversity capturing different aspects of diversity patterns in a sample or population are used, based on incidence, relative frequencies, pairwise distances, or phylogenetic trees. Here, we review and compare several of these measures.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Presentations
Fuhrmann, Lara
Read error correction for heterogeneous NGS samples using Dirichlet mixture models Presentation
Poster at Asonca 2022 - Biological systems: from first principles to data-driven modelling and back , 27.03.2022.
@misc{nokey,
title = {Read error correction for heterogeneous NGS samples using Dirichlet mixture models},
author = {Lara Fuhrmann },
url = {https://bsse.ethz.ch/cbg/cbg-news/ascona-2022.html},
year = {2022},
date = {2022-03-27},
howpublished = {Poster at Asonca 2022 - Biological systems: from first principles to data-driven modelling and back },
keywords = {},
pubstate = {published},
tppubtype = {presentation}
}
Fuhrmann, Lara
Error correction and local haplotype reconstruction for NGS data Presentation
Poster at International Virus Bioinformatics Meeting 2022, 24.03.2022.
@misc{nokey,
title = {Error correction and local haplotype reconstruction for NGS data},
author = {Lara Fuhrmann},
url = {https://evbc.uni-jena.de/events/vibiom2022/},
year = {2022},
date = {2022-03-24},
urldate = {2022-03-24},
howpublished = {Poster at International Virus Bioinformatics Meeting 2022},
keywords = {},
pubstate = {published},
tppubtype = {presentation}
}